What do you mean by "easier to work with "? If you're thinking of writing some code to pull out bits of the responses from the API and manipulate them, I'd think it would be much easier to work with the JSON directly than to first load it into Excel or Access. Or are you trying to do this without programming still, and looking for a UI that helps you look through the data yourself? Even then, I'd think a tool for viewing JSON might be more useful than loading data into Excel or Access.
Or am I missing the point of what you're doing? Maybe say a little more about what specifically you're trying to do, and I might be able to offer better advice.
-Eli